Ok now that everything but Spidey is under one umbrella I think Marvel can do themselves and US a huge favor by taking an Endgame-esq attempt at making a setup for a Secret Wars movie.
Follow me on this one....
So right now a proper reboot of Fantastic 4 would be perfect and, most likely, well written.
And with how abysmal the last X-Men movie was (and New Mutants was a disappointment too) maybe a fix/reboot of X-Men.
Once that's completed and the mutant universe is officially part of the Marvel/Disney empire, introduce new actors for certain roles and expand the MCU now they would set everything up for Secret Wars two-movie finale like they did with Infinity War/Endgame.
With the majority of players who were in the ORIGINAL comic storyline (like Avengers, Spider-Man, 3 of the Fantastic 4, X-Men (with Magneto!) and possibly Venom too if they can work it out with Sony again.